![]() ![]() Migraine is a highly prevalent brain disorder characterized by disabling attacks of moderate-to-severe pulsating and usually one-sided headache that may be aggravated by physical activity, and can be associated with symptoms such as a hypersensitivity to light and sound, nausea and vomiting 1. Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide ( CALCA/CALCB) and serotonin 1F receptor ( HTR1F). Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Nature Genetics volume 54, pages 152–160 ( 2022) Cite this article Danish Blood Donor Study Genomic Cohort,.International Headache Genetics Consortium,.Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
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